(10-14) However, beta-blockers cross the placental barrier and are associated with several adverse effects, such as delayed intrauterine growth, respiratory depression, neonatal bradycardia and hypoglycemia, particularly when treatment is started early on in the pregnancy (i.e. at 12–24 weeks).
Is beta blockers safe during pregnancy?
Beta-blockers are a first-line medication for hypertension during pregnancy and are also used during pregnancy for various other maternal cardiac conditions.
Which beta blocker is not safe in pregnancy?
Conclusions The authors found that exposure to β-blockers during pregnancy was associated with being born SGA, preterm birth and perinatal mortality. Our findings show that labetalol is not safer than other β-blockers during pregnancy.
Is propranolol contraindicated in pregnancy?
Propranolol Pregnancy Warnings
This drug is only recommended for use during pregnancy when there are no alternatives and the benefit outweighs the risk. Beta blockers may cause decreased placental perfusion, fetal and neonatal bradycardia, and hypoglycemia.
Are beta blockers teratogenic?
β-Blocker exposure has been shown to cause bradycardia and hypoglycemia in the neonate. A recent meta-analysis4 reported an association between β-blocker exposure and fetal congenital cardiovascular defects, raising a concern regarding potential teratogenic effects of this class of medication.
Are Beta Blockers Safe?
Beta blockers are generally safe to take. Side effects tend to be annoying, not life-threatening.
What are the risks of beta blockers?
The most common side effects of beta-blockers are:
- Fatigue and dizziness. Beta-blockers slow down your heart rate. …
- Poor circulation. Your heart beats more slowly when you take beta-blockers. …
- Gastrointestinal symptoms. These include upset stomach, nausea, and diarrhea or constipation. …
- Sexual dysfunction. …
- Weight gain.
12 февр. 2020 г.
Will labetalol affect my baby?
Labetalol is not thought to harm an unborn baby. But there’s a small chance that when your baby’s born the medicine can affect their blood sugar levels. For this reason your baby may be monitored for the first 24 hours to make sure everything is OK.
Is it OK to take atenolol while pregnant?
6 Atenolol appears to be safe for use in hypertensive pregnancies. Its effectiveness as an antihypertensive agent in pregnancy requires further controlled evaluation.
Can you breastfeed on beta blockers?
Propranolol is considered to be the beta blocker of choice in breastfeeding. Metoprolol is also considered to pose a low risk. Acebutolol, atenolol and nadolol are favoured least because of relatively high milk levels and possible side effects in breastfed infants.
Can propranolol cause a miscarriage?
Can taking propranolol in pregnancy cause miscarriage? A single study provided no evidence that use of propranolol in early pregnancy was linked to an increased risk of miscarriage. No further studies have assessed miscarriage rates in women taking propranolol and more research into this subject is therefore required.
What medications should not be taken with propranolol?
Some products that may interact with this drug include: alpha blockers (e.g., prazosin), aluminum hydroxide, anticholinergics (e.g., atropine, scopolamine), chlorpromazine, drugs affecting liver enzymes that remove propranolol from your body (such as cimetidine, St.
Does propranolol cross the placenta?
Propranolol does not possess ISA and is categorized as a non-selective β-blocker; moreover, it readily crosses the placenta because of its lipophilicity. Therefore, propranolol might increase vascular resistance in both the mother and fetus, yielding a higher risk of FGR.
Do beta blockers affect male fertility?
In particular, beta blockers and calcium-channel blockers (CCBs) seem to play a detrimental role on male fertility, causing in several cases azoospermia and/or oligozoospermia. On the other hand, inhibitors of the funny channel, such as oral ivabradine, seem not to be associated with reduction of male fertility.